MOSQUITO RESEARCH FOR GLOBAL PUBLIC HEALTH

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RESERACH PAPERS

• Li Z, Dong Y, You L, Corder RM, Arzobal J, Yeun A, Yang L, Marshall JM, Dimopoulos G*, Bier E*. Driving a protective allele of the mosquito FREP1 gene to combat malaria. Nature. 2025 Jul 23. doi: 10.1038/s41586-025-09283-6. Epub ahead of print. PMID: 40702179.

  *Co-communicating authors

• Cardoso-Jaime V, Tikhe CV, Tavadia M, Dimopoulos G. Aedes aegypti Hemocytes Mediate Antiviral Immunity. Int J Mol Sci. 2025 Sep 9;26(18):8779. doi: 10.3390/ijms26188779. PMID: 41009349; PMCID: PMC12470020.

• Dong Y, Kang S, Sandiford SL, Pike A, Simões ML, Ubalee R, Kobylinski K, Dimopoulos G. (2025) Targeting the mosquito prefoldin-chaperonin complex blocks Plasmodium transmission. Nat Microbiol. 2025 Apr;10(4):841-854. doi: 10.1038/s41564-025-01947-3. Epub 2025 Mar 6. PMID: 40050397.

• Cardoso-Jaime V, Dimopoulos G. (2025) Anopheles gambiae phagocytic hemocytes promote Plasmodium falciparum infection by regulating midgut epithelial integrity. Nat Commun. 2025 Feb 8;16(1):1465. doi: 10.1038/s41467-025-56313-y. PMID: 39920122; PMCID: PMC11805967.

• Dolan B, Correa Gaviria T, Dong Y, Cresswell P, Dimopoulos G, Chuang YM, Fikrig E. (2025) mosGILT antibodies interfere with Plasmodium sporogony in Anopheles gambiae. Nat Commun. 2025 Jan 11;16(1):592. doi: 10.1038/s41467-025-55902-1. PMID: 39799117; PMCID: PMC11724845.

• Kona MP, Tedjou AN, Kefi M, Buongiorno F, Wondji CS, Dimopoulos G. (2025) Off-grid field-deployable molecular diagnostic platform for malaria surveillance. Parasit Vectors. 2025 Apr 23;18(1):150. doi: 10.1186/s13071-025-06779-y. PMID: 40269892; PMCID: PMC12016468.

• Camacho E, Dong Y, Chrissian C, Cordero RJB, Saraiva RG, Anglero-Rodriguez Y, Smith DFQ, Jacobs E, Hartshorn I, Patiño-Medina JA, DePasquale M, Dziedzic A, Jedlicka A, Smith B, Mlambo G, Tripathi A, Broderick NA, Stark RE, Dimopoulos G, Casadevall A. (2025) Dietary L-3,4-dihydroxyphenylalanine (L-DOPA) augments cuticular melanization in Anopheles mosquitos while reducing their lifespan and malaria parasite burden. bioRxiv [Preprint]. 2025 Mar 20:2024.09.30.615839. doi: 10.1101/2024.09.30.615839. PMID: 40166253; PMCID: PMC11956902.

• Dong S, Tavadia M, Dong QA, Dimopoulos G. (2025) Engineered antibody-mediated broad-spectrum suppression of human arboviruses in the Aedes aegypti vector. Commun Biol. 2025 May 7;8(1):709. doi: 10.1038/s42003-025-08133-5. PMID: 40335671; PMCID: PMC12059017.

• Dong S, Ciomperlik-Patton J, Zhao Y, Dong Y, Myles KM, Dimopoulos G. (2025) Enhancing Tissue-Specific Antiviral Immunity to Disrupt Arbovirus Transmission by Mosquitoes. bioRxiv [Preprint]. 2025 Apr 4:2025.04.04.647234. doi: 10.1101/2025.04.04.647234. PMID: 40236013; PMCID: PMC11996529.

• Wood MJ, Kanelli K, Silva JJ, Couceiro JC, Papadopoulos A, Maridaki FE, Mazavli M, Siden-Kiamos I, Vontas J, Dimopoulos G. (2025) Bacteria isolated from biodiverse Mediterranean island habitats yield a large array of biopesticidal metabolites against mosquito larvae. Appl Environ Microbiol. 2025 Aug 20;91(8):e0096625. doi: 10.1128/aem.00966-25. Epub 2025 Jul 7. PMID: 40622165; PMCID: PMC12366336.

• Hardy CSC, Bahr LE, Rothman AL, Anderson KB, Barba-Spaeth G, Weiskopf D, Ooi EE, Marques ETA, Bonsignori M, Barrett ADT, Kirkpatrick BD, Castanha PMS, Hamins-Puertolas M, Christofferson RC, Dimopoulos G, Oliveira F, Chiang LW, Ko AI, Gunale B, Kulkarni P, Perkins TA, Dorigatti I, Stewart T, Shaw J, Johansson MA, Thomas SJ, Waickman AT. (2025) Proceedings of the second annual dengue endgame summit: A call to action. PLoS Negl Trop Dis. 2025 Apr 28;19(4):e0013028. doi: 10.1371/journal.pntd.0013028. PMID: 40294026; PMCID: PMC12036847.

• Tikhe CV, Issiaka I, Dong Y, Kefi M, Tavadia M, Bilgo E, Malavazi Corder R, Marshall J, Diabate A, Dimopoulos G. (2024) Chromobacterium biopesticide overcomes insecticide resistance in malaria vector mosquitoes. Sci. Adv.10,3658.DOI:10.1126/sciadv.ads3658.

• Barreto C, Cardoso-Jaime V, Dimopoulos G. (2024) A novel broad-spectrum antibacterial and anti-malarial Anopheles gambiae Cecropin promotes microbial clearance during pupation. PLoS Pathog. 20(10):e1012652. doi: 10.1371/journal.ppat.1012652. PMID: 39441862; PMCID: PMC11554196.

• Hart TM, Sonnert ND, Tang X, Chaurasia R, Allen PE, Hunt JR, Read CB, Johnson EE, Arora G, Dai Y, Cui Y, Chuang YM, Yu Q, Rahman MS, Mendes MT, Rolandelli A, Singh P, Tripathi AK, Ben Mamoun C, Caimano MJ, Radolf JD, Lin YP, Fingerle V, Margos G, Pal U, Johnson RM, Pedra JHF, Azad AF, Salje J, Dimopoulos G, Vinetz JM, Carlyon JA, Palm NW, Fikrig E, Ring AM. (2024) An atlas of human vector-borne microbe interactions reveals pathogenicity mechanisms. Cell. S0092-8674(24)00532-4. doi: 10.1016/j.cell.2024.05.023. PMID: 38876107.

• Vandana V, Dong S, Sheth T, Sun Q, Wen H, Maldonado A, Xi Z, Dimopoulos G. (2024) Wolbachia infection-responsive immune genes suppress Plasmodium falciparum infection in Anopheles stephensi. PLoS Pathog. 20(4):e1012145. doi: 10.1371/journal.ppat.1012145. PMID: 38598552; PMCID: PMC11034644.

• Arora G, Tang X, Cui Y, Yang J, Chuang YM, Joshi J, Sajid A, Dong Y, Cresswell P, Dimopoulos G, Fikrig E. (2024) mosGILT controls innate immunity and germ cell development in Anopheles gambiae. BMC Genomics. 25(1):42. doi: 10.1186/s12864-023-09887-0. PMID: 38191283; PMCID: PMC10775533.

• Chuang YM, Dong Y, Stone H, Abouneameh S, Tang XD, Raduwan H, Dimopoulos G, Fikrig E. (2024) Anopheles gambiae lacking AgTRIO probe inefficiently on a mammalian host. Cell Rep. 43(8):114600. doi: 10.1016/j.celrep. 114600.

• Dong S and Dimopoulos G (2023) Aedes aegypti Argonaute 2 controls arbovirus infection and host mortality. Nat Commun 14(1):5773.

• Carballar-Lejarazú R, Dong Y, Pham TB, Tushar T, Corder RM, Mondal A, Sánchez C HM, Lee HF, Marshall JM, Dimopoulos G, James AA. (2023) Dual effector population modification gene-drive strains of the African malaria mosquitoes, Anopheles gambiae and Anopheles coluzzii. Proc Natl Acad Sci U S A. 120(29):e2221118120.

• Belavilas-Trovas A, Tastsoglou S, Dong S, Kefi M, Tavadia M, Mathiopoulos KD, Dimopoulos G. (2023) Long non-coding RNAs regulate Aedes aegypti vector competence for Zika virus and reproduction. PLoS Pathog. 19(6):e1011440.

• Engdahl CS, Caragata EP, Tavadia M, Dimopoulos G. (2023) Chromobacterium Biopesticide Exposure Does Not Select for Resistance in Aedes Mosquitoes. mBio. 14(2):e0048023.

• Bui M, Dalla Benetta E, Dong Y, Zhao Y, Yang T, Li M, Antoshechkin IA, Buchman A, Bottino-Rojas V, James AA, Perry MW, Dimopoulos G, Akbari OS. (2023) CRISPR mediated transactivation in the human disease vector Aedes aegypti. PLoS Pathog. 19(1):e1010842.

• Villegas LEM, Radl J, Dimopoulos G, Short SM. Bacterial communities of Aedes aegypti mosquitoes differ between crop and midgut tissues. (2023) PLoS Negl Trop Dis. 17(3):e0011218.

• Samuel GH, Pohlenz T, Dong Y, Coskun N, Adelman ZN, Dimopoulos G, Myles KM. (2023) RNA interference is essential to modulating the pathogenesis of mosquito-borne viruses in the yellow fever mosquito Aedes aegypti. Proc Natl Acad Sci U S A. 120(11):e2213701120.

• Tikhe CV, Dimopoulos G. (2023) Phage Therapy for Mosquito Larval Control: a Proof-of-Principle Study. mBio. e0301722.

• Engdahl CS, Tikhe CV, Dimopoulos G. (2022) Discovery of novel natural products for mosquito control. Parasit Vectors. 15(1):481.

• Carr AL, Rinker DC, Dong Y, Dimopoulos G, Zwiebel LJ. Transcriptome profiles of Anopheles gambiae harboring natural low-level Plasmodium infection reveal adaptive advantages for the mosquito. Sci Rep. 2021 Nov 19;11(1):22578. doi: 10.1038/s41598-021-01842-x. PMID: 34799605; PMCID: PMC8604914.

• Simões ML, Dong Y, Mlambo G and Dimopoulos G (2022) C-type lectin 4 regulates broad-spectrum melanization-based refractoriness to malaria parasites. PLoS Biology, 20(1):e3001515.

REVIEW PAPERS

• Zhang X, Dimopoulos G. Wolbachia for malaria control. Trends Parasitol. 2026 Jan 7:S1471-4922(25)00358-7. doi: 10.1016/j.pt.2025.12.005. Epub ahead of print. PMID: 41506920.

• Saab SA, Cardoso-Jaime V, Kefi M, Dimopoulos G. (2025) Advances in the dissection of Anopheles-Plasmodium interactions. PLoS Pathog. 2025 Mar 31;21(3):e1012965. doi: 10.1371/journal.ppat.1012965. PMID: 40163471; PMCID: PMC11957333.

• Cai P, Dimopoulos G. Microbial biopesticides: A one health perspective on benefits and risks. One Health. 2024 Dec 29;20:100962. doi: 10.1016/j.onehlt.2024.100962. PMID: 39867997; PMCID: PMC11762943.

• Kefi M, Cardoso-Jaime V, Saab SA, Dimopoulos G. Curing mosquitoes with genetic approaches for malaria control. Trends Parasitol. 2024 Jun;40(6):487-499. doi: 10.1016/j.pt.2024.04.010. Epub 2024 May 16. PMID: 38760256.

• Arora G, Chuang YM, Sinnis P, Dimopoulos G, Fikrig E. (2023) Malaria: influence of Anopheles mosquito saliva on Plasmodium infection. Trends Immunol. 2023 Apr;44(4):256-265.

• Cardoso-Jaime V, Tikhe CV, Dong S, Dimopoulos G. The Role of Mosquito Hemocytes in Viral Infections. Viruses. 2022 Sep 20;14(10):2088. doi: 10.3390/v14102088. PMID: 36298644; PMCID: PMC9608948.

• Dong S, Dong Y, Simões ML, Dimopoulos G (2021) Mosquito transgenesis for malaria control. Trend in Parasitology, 38(1):54-66.

• Tikhe CV, Dimopoulos G. (2021) Mosquito antiviral immune pathways. Dev Comp Immunol. 116:103964.

• Dong S, Dimopoulos G. (2021) Antiviral Compounds for Blocking Arboviral Transmission in Mosquitoes. Viruses. 13(1):108. doi: 10.3390/v13010108. PMID: 33466915; PMCID: PMC7830659.

• Caragata E, Dong S, Dong Y, Simões ML, Tikhe CV, Dimopoulos G. (2020) Prospects and Pitfalls: Next-Generation Tools to Control Mosquito-transmitted Disease. Annu Rev Microbiol. 8;74:455-475.

• Saraiva RG, Dimopoulos G. (2020) Bacterial natural products in the fight against mosquito-transmitted tropical diseases. Nat Prod Rep. doi: 10.1039/c9np00042a.