Publications
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Souza-Neto JA, Sim S, and Dimopoulos G (2009) Evolutionary conserved function of the JAK-STAT pathway in anti-dengue defense. Proc. Natl. Acad. Sci. USA. Accepted for publication.
Erickson SA, Xi Z, Mayhew GF, Ramirez JL, Aliota MT, Christensen BM, Dimopoulos G (2009) Mosquito Infection Responses to Developing Filarial Worms. PLoS Trop. Negl. Dis. Accepted for publication.
Sim S, Ramirez JL, and Dimopoulos G (2009) Molecular discrimination of mosquito vectors and their pathogens. Expert Review of Molecular Diagnostics. Accepted for publication.
Baton LA, Robertson A, Warr E, Strand MR, Dimopoulos G. (2009) Genome-wide transcriptomic profiling of Anopheles gambiae hemocytes reveals pathogen-specific signatures upon bacterial challenge and Plasmodium berghei infection. BMC Genomics 10(1):257.
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Dong Y., Manfredini F. and Dimopoulos G. (2009) Implication of the Mosquito Midgut Microbiota in the Defense
Against Malaria Parasites. PLoS Pathogens,
5(5), e1000423.
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Sessions OM, Barrows, NJ, Souza-Neto JA, Robinson TJ, Hershey CL, Rodgers MA, Ramirez JL, Dimopoulos G, Yang PL, Pearson JL,
Garcia-Blanco MA (2009) Discovery of Dengue Virus Host Factors
in Insects and Humans. Nature, 458(7241):1047-1050.
Dong Y. and Dimopoulos G. (2009) Anopheles fibrinogen-related proteins provide expanded pattern recognition capacity against bacteria and malaria parasites. J Biol Chem.,
Feb 4, EPUB ahead of print.
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Garver L., Dong Y. and Dimopoulos G. (2009) Caspar control resistance to Plasmodium falciparum in diverse Anopheline species. PloS Pathogens, 5(3):e1000335.
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Das S., and Dimopoulos G. (2008) Molecular analysis of photic inhibition of blood-feeding in Anopheles gambiae. BMC Physiology 16;8(1):23.
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Abrantes A., Dimopoulos G., Grosso AR., do Rosario VE. and Silveira
H. (2008) Chloroquine mediated modulation of Anopheles gambiae gene
expression. PLoS ONE, PLoS ONE 2;3(7).
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Ramirez JL., Garver L., and Dimopoulos G. (2008) Challenges and
Approaches for Mosquito Targeted Malaria Control. Curr. Mol. Medicine 9(2):116-30.
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Xi Z., Ramirez JL., Dimopoulos G. (2008) The Aedes aegypti Toll
pathway controls dengue virus infection. PLoS Pathogens.
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Gomulski LM., Dimopoulos G., Xi Z., Soares MB., Bonaldo MF.,
Malacrida AR., Gasperi G. (2008) Gene discovery in an invasive tephritid
model pest species, the Mediterranean fruit fly, Ceratitis capitata. BMC
Genomics 2008, 9:248.
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Baton L, Garver L, Xi Z and Dimopoulos G. (2008) Functional genomics
studies on the innate immunity of disease vectors. Insect Science, 15:15-27.
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Warr, E., Das, S., Dong, Y., and Dimopoulos, G. (2008) The
Gram-Negative Bacteria-Binding Protein gene family: Its role in the innate
immune system of Anopheles gambiae and in anti-Plasmodium defense. Insect
Mol. Biol., 17:39-51.
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Garver, LS, Xi, Z and Dimopoulos, G. (2008) Immunoglobulin
superfamily members play an important role in the mosquito immune system,
Dev. & Comp. Immunol. 32:519-31.(PDF)
Aguilar, R., Das, S., Dong, Y. and Dimopoulos, G. (2007) Continuous
exposure to Plasmodium results in decreased susceptibility and
transcriptomic divergence of the Anopheles gambiae immune system. BMC
Genomics, 8:451.(PDF)
Baton, L., Warr, E., Hoffman S. and Dimopoulos, G. (2007) Programmed
cell death during malaria parasite infection of the vertebrate host and
mosquito vector. In Programmed Cell Death in Protozoa, Edited by Martin P.
Landes Bioscience, Springer. In Press.
Garver, L.S., Baton, L., and Dimopoulos, G. (2007) Mosquito Immunity
to the Malaria Parasite. In Insect Immunology, Edited by Nancy Beckage.
Elsevier. In Press.
Waterhouse, RM, Kriventseva, EV, Meister, S, Xi, Z, Alvarez, KV,
Bartholomay, LC, Barillas-Mury, C, Bian, G, Blandin, S, Christensen, BM,
Dong, Y, Jiang, H, Kanost, MR, Koutsos, AC, Levashina, EA, Li, J,
Ligoxygakis, P, MacCallum, RM, Mayhew, GF, Mendes, A, Michel, K, Osta, MA,
Paskewitz, S, Shin SW, Vlachou, D, Wang, L, Wei, W, Zheng, L, Zou, Z,
Severson, DW, Raikhel, AS, Kafatos, FC, Dimopoulos, G, Zdobnov, EM,
Christophides, GK (2007) Evolutionary dynamics of immune-related genes and
pathways in disease vector mosquitoes. Science, 316:1738-1743.
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Nene V, Wortman JR, Lawson D, Haas B, Kodira C, Tu ZJ, Loftus B, Xi
Z, Megy K, Grabherr M, Ren Q, Zdobnov EM, Lobo NF, Campbell KS, Brown SE,
Bonaldo MF, Zhu J, Sinkins SP, Hogenkamp DG, Amedo P, Arsenburger P,
Atkinson PW, Bidwell S, Biedler J, Birney E, Bruggner RV, Costas J, Coy MR,
Crabtree J, Crawford M, Debruyn B, Decaprio D, Eiglmeier K, Eisenstadt E,
El-Dorry H, Gelbart WM, Gomes SL, Hammond M, Hannick LI, Hogan JR, Holmes
MH, Jaffe D, Johnston SJ, Kennedy RC, Koo H, Kravitz S, Kriventseva EV, Kulp
D, Labutti K, Lee E, Li S, Lovin DD, Mao C, Mauceli E, Menck CF, Miller JR,
Montgomery P, Mori A, Nascimento AL, Naveira HF, Nusbaum C, O'leary SB,
Orvis J, Pertea M, Quesneville H, Reidenbach KR, Rogers YH, Roth CW,
Schneider JR, Schatz M, Shumway M, Stanke M, Stinson EO, Tubio JM, Vanzee
JP, Verjovski-Almeida S, Werner D, White O, Wyder S, Zeng Q, Zhao Q, Zhao Y,
Hill CA, Raikhel AS, Soares MB, Knudson DL, Lee NH, Galagan J, Salzberg SL,
Paulsen IT, Dimopoulos G, Collins FH, Bruce B, Fraser-Liggett CM, Severson
DW. (2007)Genome Sequence of Aedes aegypti, a Major Arbovirus Vector.
Science, 316:1718-1723.(PDF)
Warr, E., Aguilar, R., Dong, Y., Mahairaki V. and Dimopoulos, G.
(2007) Spatial and sex-specific dissection of the Anopheles gambiae midgut
transcriptome. BMC Genomics, 8:37.(PDF)
Warr, E., Lambrechts, L., Bourgouin C., Koella, J., and Dimopoulos,
G. (2006) Melanization of Sephadex Beads in Anopheles gambiae is controlled
by anti-Plasmodium immune factors. Insect Biochemistry and Molecular
Biology, 36:769-778
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Baton, L., Dong, Y., Li, J. and Dimopoulos, G. (2006) Variation in
mosquito immunity to Plasmodium. Proceedings of the 11th International
Congress of Parasitology.
Mair G., Braks J.A.M., Garver L., Wiegant J.K.A.G., Hall Dirks,
R.W., Khan S.M., Dimopoulos, G., Janse C.J., Waters A.P. (2006) Regulation
of sexual development of Plasmodium by translational repression. Science,
313(5787):667-669.(PDF)
Dong Y., Taylor H.E., and Dimopoulos, G. (2006) AgDscam, a hyper
variable immunoglobulin domain containing receptor of the Anopheles gambiae
innate immune system. PLoS Biology 4: e229.(PDF)
Dong Y., Aguilar R., Xi Z., Warr E., Mongin E., and Dimopoulos, G.
(2006) Anopheles gambiae immune responses to human and rodent Plasmodium
parasite species. PLoS Pathogens 6: 1-13.(PDF)
Heard NA, Holmes CC, Stephens DA, Hand DJ and Dimopoulos G (2005)
Bayesian Co-clustering of Anopheles Gene Expression Time Series: A Study of
Immune Defense Response To Multiple Experimental Challenges. Proc Natl Acad
Sci U S A 102:16939-16944.(PDF)
Aguilar R, Dong Y, Warr E and Dimopoulos, G. (2005) Anopheles
infection responses: laboratory models versus field malaria transmission
systems. Acta Tropica 95(3):285-291.(PDF)
Xu, XJ., Dong, Y., Abraham, EG., Kocan, A., Srinivasan, P., Sinden,
RE., Ribeiro, JMC., Jacobs-Lorena, M., Kafatos FC., and Dimopoulos, G.
(2005) Transcriptome analysis of Anopheles stephensi-Plasmodium berghei
interactions. Mol Biochem Parasitol. 142:76-87.(PDF)
Both, M., Eckert, SE., Csukai, M., Dimopoulos, G., Spanu PD. (2005)
Transcript profiles of Blumeria graminis development during infection reveal
a cluster of genes that are potential virulence determinants. Molecular
Plant-Microbe Interactions. 18(2):125-133.(PDF)
Aguilar, R., Jedlicka, AE. Mintz,M., Mahairaki, V., Scott AL. and
Dimopoulos, G. (2005) Global gene expression analysis of Anopheles gambiae
responses to microbial challenge. Insect Biochem Mol Biol. ;35:709-719.(PDF)
Abraham EG., Islam S., Srinivasan P., Ghosh AK., Valenzuela JG.,
Ribeiro LMC., Kafatos FC., Dimopoulos, G. and Jacobs-Lorena M. (2004)
Analysis of the Plasmodium and Anopheles transcriptional repertoire during
ookinete development and midgut invasion. J Biol Chem. 279: 5573-5580.
(PDF)
Srinivasan P., Abraham EG., Ghosh AK., Valenzuela J., Ribeiro JMC.,
Dimopoulos, G., Kafatos FC., Adams JH., Fujioka J and Jacobs-Lorena M.
(2004) Analysis of The Plasmodium and ANOPHELES transcriptomes during oocyst
differentiation. J Biol Chem. 279: 5581-5587.(PDF)
Wu MH, Dimopoulos G, Mantalaris A, Varley J. (2003) The effect of
hyperosmotic pressure on the antibody production and gene expression of
GS-NS0 cell line. Biotechnol Appl Biochem. Nov 13.
Kumar S., Christophides GK., Cantera R., Charles B., Soon HY.,
Meister P., Dimopoulos, G., Kafatos FC., Barillas-Mury C. (2003) The role of
Reactive Oxygen Species (ROS) on Plasmodium melanotic encapsulation in
Anophele gambiae. Proc. Natl. Acad. Sci. USA. 100: 14139- 14144.
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Dessens, JT., Sidén-Kiamos, I., Jmendoza, J., Mahairaki, V.,
Khater, E., Vlachou, D., Xu, JX., Kafatos, FC., Louis, C., Dimopoulos, G.
and Sinden, RE. (2003) SOAP, a novel malaria ookinete protein involved in
mosquito midgut invasion and oocyst development. Mol Microbiol. 49:319-329.(PDF)
Dimopoulos, G. (2003) Insect immunity and its implication in
mosquito-malaria interactions. Microreview Cell Microbiol.5: 3-14.(PDF)
Christophides GK, Zdobnov E, Barillas-Mury C, Birney E, Blandin S,
Blass C, Brey PT, Collins FH, Danielli A, Dimopoulos G, et al., (2002)
Immunity-related genes and gene families in Anopheles gambiae. Science
298:159-165.(PDF)
Zdobnov EM, von Mering C, Letunic I, Torrents D, Suyama M, Copley
RR, Christophides GK, Thomasova D, Holt RA, Subramanian GM, Mueller HM,
Dimopoulos G, etal., (2002) Comparative genome and proteome analysis of
Anopheles gambiae and Drosophila melanogaster. Science 298: 149-159.(PDF)
Dimopoulos, G., Christophides GK., Meister S., Schultz J., White KP.,
Barillas-Mury C.and Kafatos FC. (2002) Genome expression analysis of
Anopheles gambiae: Responses to injury, bacterial challenge and malaria
infection. Proc. Natl. Acad. Sci. USA. 99:8814-8819.
(PDF)
Zhang, D., Dimopoulos, G., Wolf, A., Minana, B., Kafatos, F.C. and
Winzerling, J. (2002) Cloning and molecular characterization of two mosquito
iron regulatory protein 1 genes. Insect Biochem Mol Biol. 32, 579-589.(PDF)
Dimopoulos, G., Kafatos F.C., Waters A.P., Sinden R.E. (2002)
Malaria Parasites and the Anopheles Mosquito. in Chemical Immunology Vol. 80
„Malaria Immunology“ 2nd ,pp. 27-49.
Viziol, J., Bulet, P., Hoffmann, J.A., Kafatos, F.C., Müller,
H-M and Dimopoulos, G. (2001) Gambicin: a novel immune responsive
antimicrobial peptide from the malaria vector Anopheles gambiae. Proc Natl
Acad Sci U S A 98:12630-12635.(PDF)
Dimopoulos, G., Müller, H-M, Levashina, E.A. and F.C. Kafatos
(2001) Innate immune defense against malaria infection in the mosquito. Curr.
Opin. Immunol. 13, 79-88.(PDF)
Dimopoulos, G., Casavant, L., Chang, S., Scheetz, T., Roberts, C.,
Donohue, M., Schultz, J., Benes, V., Bork, P., Ansorge, W., Soares, B. and
Kafatos, F. C. (2000) Anopheles gambie pilot gene discovery project:
Identification of novel mosquito innate immunity genes from ESTs generated
from immune competent cell lines. Proc. Natl. Acad. Sci. USA 97, 6619-6624.(PDF)
Dessens, J.T., Beetsma, A.L., Dimopoulos, G., Wengelnik, K.,
Crisanti, A., Kafatos, F.C. and Sinden, R.E. (1999). CTPR is essential for
mosquito infection by malaria ookinetes. EMBO J. 18, 6221-6227.
Muller, H.-M., Dimopoulos, G., Blass, C. and Kafatos, F.C.
(1999) A hemocyte-like cell line established from the malaria vector
Anopheles gambiae expresses six prophenoloxidase genes. J. Biol. Chem., 274,
11727-11735.(PDF)
Arcà , B., Lombardo, F., de Lara Capurro Guimarães, M.,
della Torre, A., Dimopoulos, G., James. A. A. and Coluzzi, M. (1999)
Trapping cDNAs encoding secreted proteins from the salivary glands of the
malaria vector Anopheles gambiae. Proc. Natl. Acad. Sci. USA 96, 1516-1521.(PDF)
Shen, Z., Dimopoulos, G., Kafatos, F.C. and Jacobs-Lorena, M. (1999)
A cell surface mucin specifically expressed in the midgut of the malaria
mosquito Anopheles gambiae. Proc. Natl. Acad. Sci. USA, 96, 6510-5615.(PDF)
Dimopoulos, G., Seeley, D., Wolf A. and Kafatos, F. C. (1998)
Malaria infection of the mosquito Anopheles gambiae activates immune
responsive genes during critical transition stages of the parasite life
cycle. EMBO J. 17, 6115-6123.(PDF)
Richman, A., Dimopoulos, G., Seeley, D. and Kafatos, F. C. (1997)
Plasmodium activates the innate immune response of Anopheles gambiae
mosquitoes. EMBO J. 16, 6114-6119.(PDF)
Dimopoulos, G., Richman, A., Müller, H.-M. and Kafatos, F. C.
(1997) Molecular immune responses of the mosquito Anopheles gambiae to
bacteria and malaria parasites. Proc. Natl. Acad. Sci. USA, 94, 11508-11513.(PDF)
Dimopoulos, G., Richman, A., della Torre, A., Kafatos, F. C., and
Louis, C. (1996) Identifiation and characterization of differentially
expressed cDNAs of the vector mosquito, Anopheles gambiae. Proc. Natl. Acad.
Sci USA, 93, 13066-13071.(PDF)
Dimopoulos, G., della Torre, A., Kumar, V., Kafatos, F. C., and
Louis, C. (1996) Integrated Genetic Map of Anopheles gambiae: use of RAPD
Polymorphisms for Genetic, Cytogenetic and STS landmarks. Genetics, 143,
953-960.(PDF)
Favia, G., Dimopoulos, G., della Torre, A., Toure', Y. T., Coluzzi,
M., and Louis, C. (1994) Polymorphisms detected by random PCR distinguish
between different chromosomal forms of Anopheles gambiae. Proc. Natl. Acad.
Sci. USA 91, 10315-10319.(PDF)
Favia G, Dimopoulos G, Louis C. (1994) Analysis of the Anopheles
gambiae genome using RAPD markers. Insect Mol Biol. 3: 149-157.(PDF)
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